Meet Our Team
Keith R. Jerome, MD, PhD
Associate Member, Vaccine and Infectious Disease Division / Clinical Research Division
Fred Hutchinson Cancer Research Center
Professor and Head, Virology Division / Department of Laboratory Medicine, University of Washington
Dr. Keith Jerome’s laboratory has considerable experience in the study of chronic and latent viral infections, and the mechanisms by which these viruses evade the host immune response. More recently they have sought to apply newer technologies, such as homing endonucleases, to eliminate persistent reservoirs of viruses such as HIV, hepatitis B virus, and herpes simplex virus. In addition to his basic science background, Dr. Jerome is also Head of the UW Virology Division and Director of the UW Molecular Virology Laboratory, which performs >45,000 diagnostic virology tests each year, and >100,000 research assays. He currently serves as PI for the Laboratory Core of the Hepatitis B Research Network, developing and coordinating testing and result reporting for 28 sites throughout the US and Canada.
Christine Johnston, MD, MPH
Assistant Professor, Department of Medicine, University of Washington
Affiliate Investigator, Virology and Infectious Diseases Division, Fred Hutchinson Cancer Research Center
Dr. Christine Johnston has nearly a decade of experience caring for HIV-infected patients as a primary care provider. In addition, as an infectious diseases attending physician on the Seattle Cancer Care Alliance/University of Washington cancer service, she has unique experience caring for HIV infected patients undergoing chemotherapy and stem cell transplantation. Dr. Johnston has an active clinical research program with a focus on herpes simplex virus infection. She has been the principal investigator of several observational and interventional studies in both HIV-uninfected and HIV-infected individuals. As the Associate Medical Director of the University of Washington Virology Research Clinic, she closely collaborates with basic virologists and immunologists.
Hans-Peter Kiem, MD
Member, Clinical Research Division, Fred Hutchinson Cancer Research Center
José Carreras / E. Donnall Thomas Endowed Chair for Cancer Research
Professor of Medicine / Oncology / Adjunct Professor of Pathology, University of Washington School of Medicine
Dr. Hans-Peter Kiem has more than 20 years of experience with hematopoietic cell transplantation and more than 15 years of experience with gene transfer and gene therapy studies. Dr. Kiem is Director of the preclinical and clinical vector program and thus has extensive experience in the generation and production of most viral and nonviral gene transfer techniques. A significant focus of Dr. Kiem’s lab is to use gene transfer technology to study hematopoietic stem cell biology and more recently also induced pluripotent stem cells (iPSCs). They study stem cell biology and gene transfer technologies in small and large animal models to facilitate the translation to clinical applications, with the goal of developing novel stem cell-based treatment strategies for patients with genetic, infectious and malignant diseases. Dr. Kiem currently has 2 clinical protocols to study the use of gene-modified hematopoietic stem cells in patients.
Ann E. Woolfrey, MD
Associate Member, Clinical Research Division, Fred Hutchinson Cancer Research Center
Professor, Department of Pediatrics, University of Washington
Dr. Ann Woolfrey has led more than 20 clinical protocols at FHCRC, primarily aimed at improving outcome after HCT for treatment of nonmalignant disorders. In 2010, Dr. Woolfrey helped establish the FHCRC/Harborview Hospital as a primary site in the AIDS Malignancy Consortium (AMC), and is currently principal investigator of 2 active protocols studying HCT in patients with HIV. In addition, she is Medical Director of the Unrelated Donor (URD) Program at the FHCRC/Seattle Cancer Care Alliance – one of the largest URD programs in the world. Dr. Woolfrey collaborates with laboratory investigators in a number of areas, including improving transplant outcomes, performing multi-center pilot studies and for retrospective analyses of registry data.